Epilepsy including intractable epilepsy |
- Epilepsy or seizure disorders
- Refractory epilepsy (failure of sustained seizure control despite adequate trials of two or more appropriately selected, titrated and tolerated anti-epileptic drugs)
- Fair seizure control which warrants further workup of underlying etiologies (e.g. progressive cognitive or motor decline / regression of developmental milestones)
- Stereotypic lateralized seizure which is potentially amendable by surgery (with or without identifiable lesion on neuro-imaging)
- Suitability for further drug trial or non-pharmacological treatment options such as dietary treatment or surgical intervention (e.g. epilepsy surgery, vagal nerve stimulation)
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Neurometabolic / neurodegenerative diseases / movement disorders |
Suspected neurometabolic / neurodegenerative diseases with unexplained -
- encephalopathy
- epilepsy especially intractable seizures
- leukodystrophies
- movement disorders
- multisystem involvement affecting various organs (e.g. liver, heart)
- neurological regression (motor, cognitive, sensory)
- rhabdomyolysis
- spasticity
- strokes or stroke-like episodes
Confirmed neurometabolic / neurodegenerative diseases with management difficulties that do not require strict dietary management except ketogenic / high fat diet
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Neuromuscular disorders |
The Neuromuscular Disorder Clinic provides comprehensive assessment and care for children with rare and common neuromuscular diseases with diagnostic challenge, or require specialised treatments, and for recruitment to clinical trials or clinical studies.
- Congenital myopathy
- Congenital myasthenic syndromes
- Congenital muscular dystrophy
- Limb girdle muscular dystrophy
- Duchenne muscular dystrophy
- Becker muscular dystrophy
- Facioscapulohumoral muscular dystrophy
- 5q spinal muscular atrophy
- Non-5q spinal muscular atrophy
- Myotonic dystrophy
- Myasthenia gravis
- Charcot-Marie-Tooth diseases
- Other rare neuromuscular disorders
In our Neuromuscular Disorder Clinic, we closely tie our clinical care to research development. We aim to improve care to our patients through clinical and basic research.
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