Panhypopituitarism

Definition

Panhypopituitarism is a condition in which the production and secretion of all hormones by the pituitary gland is reduced, including Growth Hormone (GH), Thyroid Stimulating Hormone (TSH), Adrenocorticotropin Hormone (ACTH), Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), Vasopressin or Anti-diuretic Hormone (ADH). Reduced hormone output could be due to problem with either the hypothalamus or pituitary gland.

Signs & Symptoms

Depends on which hormone is affected.

Affected Hormone	Signs & Symptoms
GH	Abnormal slowing of growth Prolonged jaundice in infants Small penis in males
LH/FSH	Delayed puberty Less frequent menstrual periods Small penis in males
TSH	Cold intolerance
ACTH	Low blood glucose Poor appetite Nausea or dizziness Fatigue or drowsiness
ADH	Excessive thirst and excessive urination Prolonged jaundice in infants Unusually dry skin

Diagnostic tests

Neurological & eye exam
Blood and urine tests
Imaging: X-Ray or MRI

Treatment

Drug therapy: to replace hormones
Treating the underlying etiology

Follow-up

Periodic follow-up tests for adjusting dosage levels and for repeating imaging tests or blood tests if needed.